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PIPELINE

  • R&D
  • PIPELINE

PIPELINE

Program & Project Indication Discovery Preclinical Phase Ⅰ Phase Ⅱ Phase Ⅲ NDA PARTNERS
Fibrosis
INV-001 +
 Scars
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INV-002 +
 Liver Fibrosis
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INV-005 +
 IPF
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Immune
Disease
INV-101 +
 UC
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INV-008 +
 IBD
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Inflammatory
Disease
INV-004 +
 OA
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INV-006 +
 Androgenic Alopecia
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INV-007 +
 Severe Asthma
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Cancer
INV-009 +
 Blood Cancer
Solid Tumor
(Monotherapy)
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Blood Cancer
Solid Tumor
(ADC)
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Note : IPF (Idiopathic Pulmonary Fibrosis); UC (Ulcerative Colitis); IBD (Inflammatory Bowel Disease); OA (Osteoarthritis)

INV-001

Target Type of Molecule Indication Route of Administration Status
Undisclosed Repurposed drug/
Small molecule		 Scar Topical Phase II
  • Summary INV-001 is a new drug development project of topically administered small-molecule for hypertrophic scar and keloid by inhibiting collagen production in fibroblast. Phase 2 trial is completed in Korea. In the group that received the clinical drug at a high (2%) dose for 12 weeks without major protocol violations, a statistically significant difference (p<0.05, ANCOVA; Analysis of Covariance) was observed compared to the placebo, with a 24.5% reduction in scars at week 12, as confirmed through per-protocol set. ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Publication more
    • · Benzbromarone Induces Targeted Degradation of HSP47 Protein and Improves Hypertrophic Scar Formation
    • · Topical application of INV-10000001, a first-in-class HSP47 inhibitor, attenuates hypertrophic scar in porcine and rodent animal models
    • · Identification of first-in-class HSP47 inhibitor and its suppressive role in fibrogenic and inflammatory activity in human keloid cells
    • · Identification of first-in-class HSP47 inhibitor and its suppressive role in hypertrophic scars and keloids

INV-002

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Liver Fibrosis Oral Lead Optimization

* NCE : New chemical entity

  • Summary INV-002 is a new drug development project of oral small-molecule for liver fibrosis by inhibiting collagen biosynthesis in human liver stellate cell.
    Anti-fibrotic efficacy of INV-002 has been demonstrated both in CCl₄-induced liver fibrosis mouse model and MDR2 (Multi-drug resistance 2 knock-out) mouse model. Innovo therapeutics is exploring expansion of indications to other fibrosis diseases including lung, kidney, and skin fibrosis. Preclinical study is planned to be start in the first quarter of 2025 ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Publication more

INV-005

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Idiopathic Pulmonary Fibrosis Oral Hit to Lead

* NCE : New chemical entity

  • Summary INV-005 is a new drug development project of oral small-molecule for idiopathic pulmonary fibrosis(IPF) by inhibiting enzymes involved in TGF-β signaling pathways, which are strongly associated with fibrosis. With the appreciation of the profiles of hits, KDDF (Korean drug development fund) has been sponsoring the project of lead development for 2 years.
  • Publication more

INV-101

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Ulcerative Colitis Oral Phase I

* NCE : New chemical entity

  • Summary INV-101 is an oral small-molecule drug candidate for ulcerative colitis (UC) that completed a Phase 1 clinical trial in the United States in 2025. Based on promising preclinical results, the Korean Drug Development Fund (KDDF) will sponsor the project for the next two years. INV-101 is a glycogen metabolism modulator that inhibits interactions between immune cells and epithelial cells. It demonstrated excellent safety and tolerability in a Phase 1 clinical study conducted in healthy subjects. ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Publication more
    • · Synthesis and anticancer evaluation of 6-azacyclonol-2,4,6-trimethylpyridin-3-ol derivatives: M3 muscarinic acetylcholine receptor-mediated anticancer activity of a cyclohexyl derivative in androgen-refractory prostate cancer
    • · 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

INV-008

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Inflammatory Bowel Disease Oral Preclinical

* NCE : New chemical entity

  • Summary INV-008 is a new drug development project of oral small-molecule for inflammatory bowel disease (IBD) by inhibiting enzymes associated with tissue repair, which promotes regeneration and protects multiple tissues against inflammatory immune conditions including colitis. Innovo therapeutics is exploring expansion of indication to other inflammatory diseases including idiopathic pulmonary fibrosis and sarcopenia. The preclinical studies of INV-008 have been on-going. ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Publication more

INV-004

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Osteoarthritis Intra-articular Injection Preclinical

* NCE : New chemical entity

  • Summary INV-004 is a new drug development project of intra-articular injectable small-molecule for osteoarthritis by inhibiting enzymes associated with apoptosis and inflammation of chondrocytes. In the post-traumatic osteoarthritis dog model, the drug candidate showed a significant reduction in Lamness grade. They also showed structural improvement in histological evaluation. Innovo therapeutics is exploring its potential property of Disease Modifying OsteoArthrits Drug. The preclinical studies of INV-004 have been on-going. ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Publication more
    • · Targeting NLRP3/NLRP1 Inflammasome: Preclinical Efficacy and Safety of INV-1498 for Osteoarthritis

INV-006

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Androgenic alopecia Topical Hit to Lead

* NCE : New chemical entity

  • Summary INV-006 is a new drug development project of topically administered small-molecule for androgenic alopecia by dually inhibiting enzymes associated with apoptosis of hair follicle cells and receptors of substances suppressing hair growth. Its unique mechanism enables INV-006 to promote hair growth and improve its survival rate. With the appreciation of the profiles of hits, KDDF (Korean drug development fund) has been sponsoring the project of lead development for 2 years.
  • Publication more
    • · Escin Activates Canonical Wnt/b-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3b in Cultured Human Dermal Papilla Cells

INV-007

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Severe asthma/ Cystic fibrosis Inhalation Hit to Lead

* NCE : New chemical entity

  • Summary INV-007 is a new drug development project of inhaled small-molecule for severe asthma by suppressing the function of neutrophils well known as a major cause of severe asthma, which treats patients who do not respond to conventional therapy including ICS (Inhaled corticosteroid). Innovo therapeutics is exploring expansion of indication to other inflammatory diseases including cystic fibrosis.
  • Publication more

INV-009

Target Type of Molecule Indication Route of Administration Status
Undisclosed * NCE/Small molecule Blood Cancer
Solid Tumor		 Oral or injected as
a payload in ADCs		 Hit to Lead

* NCE : New chemical entity

  • Summary INV-009 is a new drug development project targeting cancer through small molecules that inhibit enzymes associated with the metabolism and growth of cancer cells, demonstrating significant anticancer effects. Candidates could be developed both as a monotherapy and as a payload in antibody-drug conjugates, allowing it to target various types of cancer.
    ※ For business development and licensing inquiries, please contact the BD manager at bd@innovothera.com.
  • Headquater T. +82(2)-6956-8680
  • R&D T. +82(42)-721-0012
  • E. contact@innovothera.com

Innovo Therapeutics Inc.

  • Headquater : 507, 38 Mapo-daero, Mapo-gu, Seoul, 04174, Korea
  • CEO : HeeDong Park
  • Business registration number : 379-86-01520
  • R&D : C-313, 17 Techno 4-ro, Yuseong-gu, Daejeon, 34013, Korea

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